Validation of the World Health Organization-5 well-being index; assessment of maternal well-being and its associated factors

Objective: The aim of this study was to validate the World Health Organization-5 Well-Being Index (WHO-5) in a sample of pregnant Iranian women, to explore the changes in maternal well-being from pregnancy to postpartum, and to determine the factors associated with maternal well-being. Materials and Methods: This study included 341 pregnant women that presented to healthcare centers affiliated with Shahroud University of Medical Sciences, Iran, in 2011. The participants completed the General Health Questionnaire (GHQ-28) and Farsi version of WHO-5 during the third trimester of pregnancy and at 2 months postpartum. Results: Cronbach's alpha coefficient for WHO-5 items was 0.85. The correlation coefficient between WHO-5 and GHQ-28 was -0.64 (P < 0.001). Exploratory factor analysis yielded 1 factor with an eigen value equal to 3.15, which explained 63.1% of the total variance. Confirmatory factor analysis confirmed the 1-factor structure. The area under ROC curve was 0.82. A WHO-5 cut-off score of <50 exhibited optimal sensitivity (0.84) and specificity (0.59) for identifying psychological symptoms (GHQ-28 score ≥24). There was a significant difference between third trimester (58.4 ± 22) and postpartum (64.1 ± 22.3) mean WHO-5 scores (P < 0.001). Maternal level of education (OR = 1.130; 95% CI: 1.307, 1.232) was the only predictor of maternal well-being during third trimester. Breastfeeding difficulty (OR = 0.923; 95% CI: 0.882, 0.965) and maternal well-being scores during third trimester (OR = 1.038; 95% CI: 1.019, 1.058) were predictors of maternal well-being during the postpartum period. Conclusions: The Farsi version of WHO-5 was observed to be a reliable and valid instrument for screening psychological symptoms in pregnant Iranian women. The present findings show that maternal well-being improved following childbirth

Quality of life after cesarean and vaginal delivery

Objective: Cesarean rates in recent decades have been increasing and a number of studies have shown that cesarean increases maternal morbidities. The aim of this study is to compare the quality of life after cesarean and vaginal delivery. Methods: This prospective study was carried out on 356 pregnant women visiting urban health centers in Shahroud City, Northeast Iran, in 2011. The subjects completed the quality of life questionnaire in the third trimester of pregnancy and at 8 weeks postpartum. Results: In primiparas, the mean global QOL scores for the cesarean and vaginal delivery groups were 67.65±12.7 and 72.12±11.8, respectively. Also, the scores for the physical, psychological and social domains of QOL as well as the global score of QOL were higher in the vaginal delivery group than the cesarean group (p<0.05). In the case of primiparas, multiple regression analysis revealed that after adjusting for education, desirability of pregnancy and the General Health Questionnaire score, the delivery type remained as a predictor of the scores for the physical (R2=1.7%; B=-3.826; p=0.031; CI [-7.301, -.350]) and social (R2=2.5%; B=-5.708; p=0.017; CI [-10.392, -1.023]) domains of QOL and the global QOL score (R2=2.6%; B=-4.065; p=0.006; CI [-6.964, -1.164]). While multiparas, there was no relationship between QOL and type of delivery. Conclusion: In this sample of low-risk women, cesarean negatively affected the QOL of primiparas. More studies with larger sample sizes should be conducted to examine the effects of cesarean on QOL in both primiparas and multiparas within a shorter period after delivery. © OMSB, 2013

Stabilization of internal space in noncommutative multidimensional cosmology

We study the cosmological aspects of a noncommutative, multidimensional universe where the matter source is assumed to be a scalar field which does not commute with the internal scale factor. We show that such noncommutativity results in the internal dimensions being stabilizedComment: 8 pages, 1 figure, to appear in IJMP

A case report presentation of coronary dissection with abrupt closure extending to left main stem following coronary angioplasty

انجام عمل آنژیوبلاستی کرونری از زمان اولین عمل توسط گرونزویک به گونه ای سیر صعودی داشته که در حال حاضر اکثر بیماران با آنژیوبلاستی و یا تعبیه استنت به زندگی روزمره خویش باز می گردند. انجام آنژیوبلاستی با ضریب موفقیت بالای 90 و عوارض و خطرات جدی کمتر از 5 همراه است. مهمترین عارضه آنژیوبلاستی کرونری انسداد ناگهانی رگ می باشد. در این مقاله مورد استثنایی از انسداد ناگهانی و دیسکشن شریان قدامی نزولی چپ متعاقب آنژیو پلاستی گزارش می گردد که بداخل تنه اصلی و شریان چرخشی کرونر چپ گسترش یافته و با درمان سریع (تعبیه به موقع استنت در مسیرهای مبتلا و منجمله تنه اصلی کرونر چپ) بیمار از مرگ قریب الوقوع نجات یافته است

Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population

In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108-1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147-3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05-2.21) p = 0.026)] and 1.74 [95% CI (1.01-3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM. © 2012, Sociedade Brasileira de Genética

Horizon Problem Remediation via Deformed Phase Space

We investigate the effects of a special kind of dynamical deformation between the momenta of the scalar field of the Brans-Dicke theory and the scale factor of the FRW metric. This special choice of deformation includes linearly a deformation parameter. We trace the deformation footprints in the cosmological equations of motion when the BD coupling parameter goes to infinity. One class of the solutions gives a constant scale factor in the late time that confirms the previous result obtained via another approach in the literature. This effect can be interpreted as a quantum gravity footprint in the coarse grained explanation. The another class of the solutions removes the big bang singularity, and the accelerating expansion region has an infinite temporal range which overcomes the horizon problem. After this epoch, there is a graceful exiting by which the universe enters in the radiation dominated era.Comment: 13 pages, 2 figures, to appear in GER